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HIV protease inhibitor drugs such as Crixivan Tiagabine (Gabitril) at certain dosage levels, or with increases in dose, may induce seizures even in those who have never had them. It may also cause problems with concentration, drowsiness, and dizziness.

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Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is as shown:

16. Perez-Molina JA, Domingo P, Martinez E, Moreno S "The role of efavirenz compared with protease inhibitors in the body fat changes associated with highly active antiretroviral therapy." J Antimicrob Chemother 62 (2008): 234-45

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