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Vardenafil was not mutagenic as assessed in either the in vitro bacterial Ames assay or the forward mutation assay in Chinese hamster V79 cells. Vardenafil was not clastogenic as assessed in either the in vitro chromosomal aberration test or the in vivo mouse micronucleus test.

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Physicians should advise patients to stop use of all PDE5 inhibitors, including Viagra, and seek medical attention in the event of a sudden loss of vision in one or both eyes. Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including possible permanent loss of vision, that has been reported rarely post-marketing in temporal association with the use of all PDE5 inhibitors. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors. Physicians should discuss with patients the increased risk of NAION in individuals who have already experienced NAION in one eye. Physicians should also discuss with patients the increased risk of NAION among the general population in patients with a "crowded" optic disc, although evidence is insufficient to support screening of prospective users of PDE5 inhibitor, including Viagra, for this uncommon condition [see Warnings and Precautions (5.3) and Adverse Reactions (6.2)].if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). is there a generic viagra erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis)

If your doctor tells you to stop taking Viagra, or the tablets have passed their expiry date, ask your pharmacist what to do with any left over. Consideration of Other Urological Conditions Prior to Initiating Treatment for BPH

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